Coagulopathy in Acute Puumala Hantavirus Infection

Viruses

Lotta Joutsi-Korhonen¹  Ilkka Pörsti²  Sirpa Koskela²  Jukka Mustonen²  Satu Mäkelä²  Outi Laine²  Tuula Outinen²  Tomas Strandin³  Antti Vaheri³ 

[1] Department of Clinical Chemistry, University of Helsinki and Helsinki University Hospital, 00290 Helsinki, Finland;Department of Internal Medicine, Tampere University Hospital, Elämänaukio 2, 33520 Tampere, Finland;Department of Virology, Medicum, University of Helsinki, Haartmaninkatu 21, 00014 Helsinki, Finland;

关键词: Puumala hantavirus;    coagulation;    complement system;    fibrinolysis;    endothelium;    platelet;   

DOI  :  10.3390/v13081553

来源: DOAJ

【 摘 要 】

Puumala hantavirus (PUUV) causes a hemorrhagic fever with renal syndrome (HFRS), also called nephropathia epidemica (NE), which is mainly endemic in Europe and Russia. The clinical features include a low platelet count, altered coagulation, endothelial activation, and acute kidney injury (AKI). Multiple connections between coagulation pathways and inflammatory mediators, as well as complement and kallikrein–kinin systems, have been reported. The bleeding symptoms are usually mild. PUUV-infected patients also have an increased risk for disseminated intravascular coagulation (DIC) and thrombosis.

【 授权许可】

Unknown