Peering into the ‘black box’ of pathogen recognition by cellular autophagy systems

Microbial Cell

Rodney J Devenish¹  Shu-chin Lai² 

[1] Oklahoma 73104, U.S.A.;Current address: Immunobiology and Cancer Research Program, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City;

关键词: autophagy;    E3 ligase;    galectin-8;    tripartite motif proteins;    ubiquitin;   

DOI  :  10.15698/mic2015.09.225

来源: DOAJ

【 摘 要 】

Autophagy is an intracellular process that plays an important role inprotectingeukaryoticcellsandmaintainingintracellularhomeostasis. Pathogens, including bacteria and viruses, that enter cells can signal induction of selective autophagy resulting in degradation of the pathogen in the autolysosome.Undersuchcircumstances,thespecificrecognitionandtargetingof the invading pathogen becomes a crucial step for the subsequent initiation of selective autophagosome formation. However, the nature of the signal(s) on thepathogensurfaceandtheidentityofhostmolecule(s)thatpresumably bindthesignalmoleculesremainrelativelypoorly characterized.Inthisreview we summarise the available evidence regarding the specific recognition of invading pathogens by which they are targeted into host autophagy pathways.

【 授权许可】

Unknown