The Effect of Pregabalin on the Minimum Alveolar Concentration of Sevoflurane: A Randomized, Placebo-Controlled, Double-Blind Clinical Trial

Frontiers in Medicine

Alexandra Graf¹  Thomas Stimpfl²  Walter Plöchl³  Johannes Müller³  Thomas Hamp³  Paul Mühlbacher³ 

[1] Center for Medical Statistics, Informatics and Intelligent Systems, Institute for Medical Statistics, Medical University of Vienna, Vienna, Austria;Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria;Division of General Anaesthesia and Intensive Care Medicine, Department of Anaesthesia, Intensive Care and Pain Medicine, Medical University of Vienna, Vienna, Austria;

关键词: pregabalin;    minimum alveolar concentration (MAC);    sevoflurane;    anesthesia;    depth of anesthesia;    premedication before anesthesia;   

DOI  :  10.3389/fmed.2022.883181

来源: DOAJ

【 摘 要 】

BackgroundPregabalin is commonly used perioperatively to reduce post-operative pain and opioid consumption and to prevent the development of chronic pain. It has been shown to reduce anesthetic consumption in balanced anesthesia, but studies investigating its effect on the minimum alveolar concentration (MAC) of volatile anesthetics are lacking. The aim of this study was to investigate the effect of two different doses of pregabalin on the MAC of sevoflurane.MethodsIn a randomized, double-blinded, placebo controlled clinical study, 75 patients were assigned to receive placebo, 300 mg pregabalin, or 150 mg pregabalin, as a capsule 1 h before anesthesia induction with sevoflurane only. After equilibration, the response to skin incision (movement vs. non-movement) was monitored. The MAC was assessed using an up- and down-titration method.ResultsThe MAC of sevoflurane was estimated as 2.16% (95% CI, 2.07–2.32%) in the placebo group, 1.44% (95% CI, 1.26–1.70%) in the 300 mg pregabalin group, and 1.81% (95% CI, 1.49–2.13%) in the 150 mg pregabalin group. We therefore report a 33% reduction in the MAC of sevoflurane in the 300 mg pregabalin group as compared to placebo. The MAC of the 150 mg pregabalin group was reduced by 16% as compared to placebo but was not statistically significant.ConclusionsThe administration of 300 mg pregabalin reduced the MAC of sevoflurane by 33%, while the administration of 150 mg pregabalin did not significantly reduce the MAC of sevoflurane. Pregabalin use led to a small reduction in post-operative pain levels but increased side effects in a dose-dependent manner.

【 授权许可】

Unknown