Thiodiketopiperazines Produced by Penicillium crustosum and Their Activities to Promote Gastrointestinal Motility

Molecules

Jing Yang¹  Yu-Cheng Gu²  Zhen Zhang³  Dan Feng³  Ling Qiu³  Yu-Zhi Li³  Feng Ju³  Lu Tan³  Xin He³  Yun Deng³  Da-Le Guo³ 

[1] State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;Syngenta Jealott’s Hill International Research Centre, Berkshire RG42 6EY, UK;The Ministry of Education Key Laboratory of Standardization of Chinese Herbal Medicine, State Key Laboratory, Breeding Base of Systematic Research Development and Utilization of Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China;

关键词: Penicillium crustosum;    Isaria cicadae;    thiodiketopiperazines;    Mosher analysis;    ECD calculation;    gastrointestinal motility;   

DOI  :  10.3390/molecules24020299

来源: DOAJ

【 摘 要 】

Three new thiodiketopiperazines (1–3), along with two known analogues (4 and 5), were isolated from the fermentation broth of Penicillium crustosum. Their structures were elucidated through extensive spectroscopic analysis and the absolute configurations of new compounds were determined by Mosher ester analysis and calculated ECD spectra. Compound 4 and 5 have the activity to promote the gastrointestinal motility of zebrafish via acting on the cholinergic nervous system.

【 授权许可】

Unknown