Prevalence and comorbidity of attention deficit hyperactivity disorder in Spain: study protocol for extending a systematic review with updated meta-analysis of observational studies

Systematic Reviews

Ferrán Catalá-López¹  Adolfo Alonso-Arroyo²  Rafael Tabarés-Seisdedos³  Ricard Gènova-Maleras⁴  Miguel A. Catalá⁵  Amparo Núñez-Beltrán⁶  Rafael Aleixandre-Benavent⁷  Manuel Ridao⁸ 

[1] Department of Health Planning and Economics, National School of Public Health, Institute of Health Carlos III;Department of History of Science and Documentation, University of Valencia;Department of Medicine, University of Valencia/INCLIVA Health Research Institute and CIBERSAM;Directorate General for Public Health, Madrid Regional Health Council;Faculty of Medicine, University of Valencia;Independent Clinical Psychologist and Researcher;Information and Social and Health Research Unit (UISYS), University of Valencia and Spanish National Research Council (CSIC);Instituto Aragonés de Ciencias de la Salud (IACS), Red de Investigación en Servicios de Salud en Enfermedades Crónicas (REDISSEC);

关键词: Attention deficit hyperactivity disorder;    Comorbidity;    Epidemiological study;    Meta-analysis;    Prevalence;    Spain;   

DOI  :  10.1186/s13643-019-0967-y

来源: DOAJ

【 摘 要 】

Abstract Background Attention deficit hyperactivity disorder (ADHD) is a childhood-onset disorder characterized by a persistent pattern of symptoms of developmentally inappropriate and impaired inattention and/or hyperactivity/impulsivity, with difficulties often continuing into adulthood. ADHD can come with other comorbid conditions. The aim of this study will be to quantify the prevalence and comorbidity of ADHD among children, adolescent, and adult population in Spain. Methods/design We designed and registered a study protocol for an update and expansion of a systematic review and meta-analysis of pooled prevalence data. We will include cross-sectional observational studies reporting prevalence of ADHD in Spain and conducted in the general population, outpatient, and/or school settings. The primary outcome will be the prevalence of ADHD. Secondary outcomes will be the prevalence of any physical or mental comorbidity in association with ADHD. No limitations will be imposed on publication status, study conduct period, and language of dissemination. Comprehensive literature searches will be conducted in multiple electronic databases, including PubMed/MEDLINE, EMBASE, Scopus, Web of Science, PsycINFO, IME – Spanish Medical Index, and IBECS – Spanish Bibliographic Index of Health Sciences. We will also search Google Scholar, dissertation databases, and conference abstracts. Two team members will independently screen all citations, full-text articles, and abstract data. Potential conflicts will be resolved through discussion. The methodological quality (or risk of bias) of individual studies will be appraised using an appropriate tool. If feasible, we will conduct random effects meta-analysis. Prevalence estimates will be stratified according to gender, age, and geographical location. Additional analyses will be conducted to explore the potential sources of heterogeneity (e.g., methodological quality, sample size, diagnostic criteria). Discussion This systematic review and meta-analysis of observational data will provide an updated synthesis of the prevalence and comorbidity of ADHD in Spain. This study will also examine factors that may explain potential variations in prevalence data. The findings of this study will be published in a peer-reviewed journal. Systematic review registration PROSPERO CRD42018106082.

【 授权许可】

Unknown