COX2 expression is associated with proliferation and tumor extension in vestibular schwannoma but is not influenced by acetylsalicylic acid intake

Acta Neuropathologica Communications

Jens Schittenhelm¹  Antje Bornemann¹  Vanessa Ries²  Marcos Tatagiba²  Marco Skardelly²  Felix Behling²  Martin Schuhmann²  Irina Gepfner-Tuma³  Florian-Heinrich Ebner⁴  Ghazaleh Tabatabai⁵ 

[1] Department of Neuropathology, Eberhard-Karls-University;Department of Neurosurgery, Eberhard-Karls University;Department of Vascular Neurology, University Hospital Tuebingen, Eberhard Karls University;Eberhard-Karls University;Interdisciplinary Division of Neuro-Oncology, Departments of Vascular Neurology and Neurosurgery, University Hospital Tuebingen, Eberhard Karls University;

关键词: Cyclooxygenase 2;    Acetylsalicylic acid;    Aspirin;    Vestibular schwannoma;    Acoustic neuroma;    Neurofibromatosis;   

DOI  :  10.1186/s40478-019-0760-0

来源: DOAJ

【 摘 要 】

Abstract Acetylsalicylic acid has been linked to a lower risk for different cancer types, presumably through its inhibitory effect on cyclooxygenase 2. This has also been investigated in vestibular schwannomas with promising results suggesting an antiproliferative effect and recently the intake has been recommended for vestibular schwannomas as a conservative treatment option. We constructed tissue microarrays from paraffin-embedded tissue samples of 1048 vestibular schwannomas and analyzed the expression of cyclooxygenase 2 and the proliferation marker MIB1 (Molecular Immunology Borstel) via immunohistochemistry together with clinical data (age, gender, tumor extension, prior radiotherapy, neurofibromatosis type 2, tumor recurrence, cyclooxygenase 2 responsive medication). Univariate analysis showed that cyclooxygenase 2 expression was increased with age, female gender, prior radiotherapy and larger tumor extension. MIB1 expression was also associated with higher cyclooxygenase 2 expression. Schwannomas of neurofibromatosis type 2 patients had lower cyclooxygenase 2 levels. Use of acetylsalicylic acid, non-steroidal anti-inflammatory drugs, glucocorticoids or other immunosuppressants did not show differences in cyclooxygenase 2 or MIB1 expression. Instead, cyclooxygenase 2 expression increases with tumor extension while MIB1 expression is not associated with tumor size. Overall, cyclooxygenase 2 expression is associated with proliferation but not influenced by regular intake of acetylsalicylic acid or other cyclooxygenase 2-responsive medications. Acetylsalicylic acid intake does not alter cyclooxygenase 2 expression and has no antiproliferative effect in vestibular.

【 授权许可】

Unknown