Apicobasal polarity and its role in cancer progression

Biomolecular Concepts

Hawrot Hannah¹  Lo Priscilla¹  Georgiou Marios¹ 

[1] School of Biomedical Sciences, University of Nottingham, University of Nottingham Medical School, Queen’s Medical Centre, Nottingham, NG7 2UH, UK;

关键词: cancer;    epigenetics;    epithelial cell polarity;    invasion;    metastasis;   

DOI  :  10.1515/bmc-2012-0020

来源: DOAJ

【 摘 要 】

Appropriate establishment and maintenance of cell polarity is essential for normal development and homeostasis. The vast majority of human cancers originate from epithelial tissues and tumour cell invasion and metastasis are the major cause of mortality in human cancers. Invading cells demonstrate loss of cell polarity, loss of epithelial cell-cell adhesions and tissue disorganisation. We examine the growing evidence linking loss of apicobasal polarity with tumour progression.

【 授权许可】

Unknown