The BDNF/TrkB Neurotrophin System in the Sensory Organs of Zebrafish

International Journal of Molecular Sciences

Teresa Cobo¹  Gabriel Capitelli²  José A. Vega³  Marzio Cometa⁴  Rosaria Laurà⁴  Francesco Abbate⁴  Maria Levanti⁴  Marialuisa Aragona⁴  Giuseppe Montalbano⁴  Antonino Germanà⁴  Caterina Porcino⁴  Maria Cristina Guerrera⁴ 

[1] Departamento de Cirugía y Especialidades Médico-Quirúrgicas, Universidad de Oviedo, 33006 Oviedo, Spain;Faculty of Medical Sciences, University of Buenos Aires, Viamonte 1053, CABA, Buenos Aires 1056, Argentina;Grupo SINPOS, Universidad de Oviedo, 33003 Oviedo, Spain;Zebrafish Neuromorphology Lab, Department of Veterinary Sciences, University of Messina, 98168 Messina, Italy;

关键词: BDNF;    TrkB receptor;    neurotrophins;    zebrafish;    sensory systems;   

DOI  :  10.3390/ijms23052621

来源: DOAJ

【 摘 要 】

The brain-derived neurotrophic factor (BDNF) was discovered in the last century, and identified as a member of the neurotrophin family. BDNF shares approximately 50% of its amino acid with other neurotrophins such as NGF, NT-3 and NT-4/5, and its linear amino acid sequences in zebrafish (Danio rerio) and human are 91% identical. BDNF functions can be mediated by two categories of receptors: p75NTR and Trk. Intriguingly, BDNF receptors were highly conserved in the process of evolution, as were the other NTs’ receptors. In this review, we update current knowledge about the distribution and functions of the BDNF-TrkB system in the sensory organs of zebrafish. In fish, particularly in zebrafish, the distribution and functions of BDNF and TrkB in the brain have been widely studied. Both components of the system, associated or segregated, are also present outside the central nervous system, especially in sensory organs including the inner ear, lateral line system, retina, taste buds and olfactory epithelium.

【 授权许可】

Unknown