Dual-target anti-Alzheimer’s disease agents with both iron ion chelating and monoamine oxidase-B inhibitory activity

Journal of Enzyme Inhibition and Medicinal Chemistry

Sihang Yu¹  Tao Zhou²  Jing Su²  Jianan Guo³  Zhisheng Mi³  Yuanyuan Xie³  Xiaoying Jiang³  Changjun Zhang³  Renren Bai³  Bing Gan³ 

[1] College of Basic Medical Sciences, Jilin University;Zhejiang Gongshang University;Zhejiang University of Technology;

关键词: alzheimer’s disease;    iron ion chelation;    mao-b;    coumarin derivatives;    hydroxypyridinone;   

DOI  :  10.1080/14756366.2019.1634703

来源: DOAJ

【 摘 要 】

MAO-B leads to an increase in the levels of hydrogen peroxide and oxidative free radicals, which contribute to the aetiology of the AD. Thus, both iron ion chelators and MAO-B inhibitors can be used to treat AD. Taking the coumarin derivatives and hydroxypyridinones as the lead compounds, a series of dual-target hybrids were designed and synthesised by Click Chemistry. The compounds were biologically evaluated for their iron ion chelating and MAO-B inhibitory activity. Most of the compounds displayed excellent iron ion chelating activity and moderate to good anti-MAO-B activity. Compounds 27b and 27j exhibited the most potent MAO-B inhibitory activity, with IC50 values of 0.68 and 0.86 μM, respectively. In summary, these dual-target compounds have the potential anti-AD activity.

【 授权许可】

Unknown