Adipocytokines in obese Ghanaian subjects with or without type 2 diabetes

BMC Research Notes

Grace Korkor Ababio¹  Yussif Adams²  Seth D. Amanquah³  Henry Asare-Anane³  Richard Nabia⁴  Emmanuel Abendau⁵  Emmanuel Kwaku Ofori⁶ 

[1] Department of Biochemistry, S.B.A.H.S;Department of Biomedical and Laboratory Sciences, University of Development Studies;Department of Chemical Pathology, School of Biomedical and Allied Health Sciences (S.B.A.H.S), University of Ghana;Department of Nutrition and Dietetics, S.B.A.H.S;Department of Physiology, S.B.A.H.S;Department of Physiology, University of Lausanne;

关键词: Leptin;    Obesity;    C-reactive protein;    Type 2 diabetes;   

DOI  :  10.1186/s13104-018-3149-4

来源: DOAJ

【 摘 要 】

Abstract Objective This study aimed to evaluate serum leptin and high sensitivity C-reactive protein (hsCRP) concentrations in obese Ghanaians with or without type 2 diabetes and to find out the extent to which their levels are influenced by underlying disorders. Results Obese subjects with type 2 diabetes had lower leptin but higher hsCRP levels compared with obese non-diabetic controls. There were negative correlations within the control group for glucose vs % muscle mass (r = − 0.378, p = 0.016), leptin vs % muscle mass (r = − 0.555, p = 0.001) and within the obese diabetic group for leptin vs % muscle mass (r = − 0.602, p = 0.001). Obese persons without diabetes were about three times more likely to have higher leptin levels compared with their obese diabetic counterparts (Odds ratio = 3.315, p < 0.001). Obese females independently had a tenfold increase in leptin levels compared with obese males.

【 授权许可】

Unknown