Thyroid hormone status in Ghanaian patients with chronic kidney disease

The Pan African Medical Journal

Nii Ayite Aryee¹  Benjamin Ako-Boham²  Emmanuel Ayitey Tagoe²  Anomah²  David Nana Adjei² 

[1] Department of Medical Biochemistry, School of Biomedical and Allied Health Sciences, College of Health Sciences, Korle-Bu, Accra, Ghana;Department of Medical Laboratory Sciences, School of Biomedical and Allied Health Sciences, College of Health Sciences, Korle-Bu, Accra, Ghana;

关键词: thyroid hormone status;    ckd;    ghanaian;    lipid profile;    tsh;    ft3;    ft4;   

DOI  :  10.11604/pamj.2018.29.137.12992

来源: DOAJ

【 摘 要 】

INTRODUCTION: There is limited data on the prevalence of thyroid dysfunction in Ghanaian individuals with chronic kidney disease (CKD). Studies exploring the effect of thyroid hormones on renal function decline are also scant. Unrecognized thyroid dysfunction in CKD may increase the burden of adverse health outcomes. The aim of this study was to determine thyroid hormone status and lipid profiles in patients with CKD attending the Renal Unit of the Korle-Bu Teaching Hospital. METHODS: 60 clinically euthyroid patients with CKD, and 65 clinically euthyroid subjects without CKD were recruited for this study. Estimation of effective glomerular filtration rate (eGFR) was done using the 4-variable Modification of Diet in Renal Disease (MDRD) formula with subsequent staging of CKD (stages 2-4). Collected venous blood samples from all study participants were analyzed for creatinine, free triiodothyronine (FT3), free thyroxine (FT4), thyroid stimulating hormone (TSH), total cholesterol (TC), high density lipoprotein (HDL) cholesterol, low density lipoprotein (LDL) and triglycerides (TG). RESULTS: levels of TC, HDL, LDL, and TSH levels did not differ significantly between the two study groups. However, TG, VLDL, FT3 and FT4 levels were significantly higher in CKD patients than in the control group. TC, TG, HDL, LDL, VLDL and TSH levels were not significantly different between stages of CKD in study subjects, although FT4 and FT3 levels were significantly different between all stages of CKD. CONCLUSION: higher levels of FT3 and FT4 but not TSH, are associated with incident CKD and eGFR decline in Ghanaian CKD patients.

【 授权许可】

Unknown