LTα, TNF, and ILC3 in Peyer’s Patch Organogenesis

Cells

Dmitry V. Kuprash¹  Sergei I. Grivennikov¹  Violetta S. Gogoleva¹  Andrey A. Kruglov¹  Sergei A. Nedospasov¹  Alexei V. Tumanov² 

[1] Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia;Department of Microbiology, Immunology and Molecular Genetics, University of Texas Health Science Center, San Antonio, TX 78229, USA;

关键词: TNF;    lymphotoxin;    Peyer’s patches;    lymphoid tissue organogenesis;    innate lymphoid cells;   

DOI  :  10.3390/cells11121970

来源: DOAJ

【 摘 要 】

TNF and LTα are structurally related cytokines of the TNF superfamily. Their genes are located in close proximity to each other and to the Ltb gene within the TNF/LT locus inside MHC. Unlike Ltb, transcription of Tnf and of Lta is tightly controlled, with the Tnf gene being an immediate early gene that is rapidly induced in response to various inflammatory stimuli. Genes of the TNF/LT locus play a crucial role in lymphoid tissue organogenesis, although some aspects of their specific contribution remain controversial. Here, we present new findings and discuss the distinct contribution of TNF produced by ILC3 cells to Peyer’s patch organogenesis.

【 授权许可】

Unknown