Contribution of Autophagy-Lysosomal Pathway in the Exosomal Secretion of Alpha-Synuclein and Its Impact in the Progression of Parkinson’s Disease

Frontiers in Molecular Neuroscience

Melissa Nassif³  Javiera Arcos⁴  Denisse Sepúlveda⁴  René L. Vidal⁴  Marisol Cisternas-Olmedo⁴ 

[1] Biomedical Neuroscience Institute, University of Chile, Santiago, Chile;Center for Integrative Biology, Facultad de Ciencias, Universidad Mayor, Santiago, Chile;Escuela de Biotecnología, Facultad de Ciencias, Universidad Mayor, Santiago, Chile;Geroscience Center for Brain Health and Metabolism, Santiago, Chile;

关键词: autophagy-lysosomal pathway;    α-syn exosomal secretion;    Parkinson’s disease progression;    biomarker;    degradation;   

DOI  :  10.3389/fnmol.2022.805087

来源: DOAJ

【 摘 要 】

Parkinson’s disease (PD) is caused by the degeneration of dopaminergic neurons due to an accumulation of intraneuronal abnormal alpha-synuclein (α-syn) protein aggregates. It has been reported that the levels of exosomal α-syn of neuronal origin in plasma correlate significantly with motor dysfunction, highlighting the exosomes containing α-syn as a potential biomarker of PD. In addition, it has been found that the selective autophagy-lysosomal pathway (ALP) contributes to the secretion of misfolded proteins involved in neurodegenerative diseases. In this review, we describe the evidence that supports the relationship between the ALP and α-syn exosomal secretion on the PD progression and its implications in the diagnosis and progression of this pathology.

【 授权许可】

Unknown