Mannotriose induced differentiation of mesenchymal stem cells into neuron-like cells

Journal of Integrative Neuroscience

Li-MingJi¹  Xiao-LanLian²  Li-NaZhang² 

[1] Department of Endocrinology, Shanghai Jing’an Shibei Hospital, 200435 Shanghai, P. R. China;Institute of Basic Medicine, Shanghai University of Traditional Chinese Medicine, 201203 Shanghai, P. R. China;

关键词: genetics;    mannotriose;    mesenchymal stem cell;    differentiation;    neuron-like cells;    herbal medicine;   

DOI  :  10.31083/j.jin.2021.01.214

来源: DOAJ

【 摘 要 】

This article demonstrates that mannotriose effectively induces the differentiation of mesenchymal stem cells into neuron-like cells in vitro. Rat-derived mesenchymal stem cells were investigated on their potential to differentiate into neuron-like cells induced by mannotriose purified from Radix Rehmanniae Preparata in vitro. The percentage of the neuron-specific enolase positive cells and the Nissl positive cells after mannotriose treatment was increased. The mRNA levels of neurofilament medium and neuron-specific enolase were upregulated in the mannotriose group compared to the control. These findings demonstrate that mannotriose purified from Radix Rehmanniae Preparata can effectively induce differentiation of rat-derived mesenchymal stem cells into neuron-like cells.

【 授权许可】

Unknown