Alcohol abuse as a risk factor for developing thyroid cancer

Srpski Arhiv za Celokupno Lekarstvo

Jovanović Milan¹  Kočica Mladen¹  Karadžić-Kočica Milica¹  Tošković Anka¹  Dimić Nemanja²  Kalezić Nevena³  Dimitrijević Ivan³ 

[1] Clinical Center of Serbia, Belgrade, Serbia;Dr. Dragiša Mišović Clinical Hospital Center, Belgrade, Serbia;University of Belgrade, Faculty of Medicine, Belgrade, Serbia + Clinical Center of Serbia, Belgrade, Serbia;

关键词: thyroid cancer;    papillary cancer;    medullary cancer;    anaplastic cancer;    follicular cancer;    alcohol abuse;   

DOI  :  10.2298/SARH201123113K

来源: DOAJ

【 摘 要 】

Introduction/Objective. Alcohol abuse influence on developing thyroid cancer is controversial. While some studies consider it a protective factor, others deny any impact on thyroid cancer. The objective of the paper was to establish a possible link between alcohol abuse and certain types of thyroid cancers. Methods. The retrospective study included 502 patients with thyroid cancer and a control group of 600 patients with benign forms of thyroid diseases (e.g. nodular, multinodular, and toxic nodular goiter). Thyroid cancer patients were divided into four groups: I – papillary, II – medullary, III – anaplastic, and IV – follicular carcinoma, and grouped by sex, age (< 30 years; > 30 years) and alcohol abuse, as defined by the World Health Organization. Results. Thyroid cancer patients were predominantly male of younger age. This distribution difference was statistically significant in groups I and II (p < 0.001). Of total 10 (0.9%) patients with chronic alcohol abuse, eight (1.6%) had thyroid cancer, while two (0.3%) belonged to the control group (p < 0.001). In thyroid cancer patients, chronic alcohol abuse was absent from groups III and IV. Distribution in groups I and II was six (1.6%) and two (2%), respectively (p < 0.001). Conclusion. Alcohol abuse deserves to be considered as a risk factor for papillary and medullary forms of thyroid cancer, while it does not stay the same for anaplastic and follicular thyroid cancers.

【 授权许可】

Unknown