Decrease in Salivary Serotonin in Response to Probiotic Supplementation With Saccharomyces boulardii in Healthy Volunteers Under Psychological Stress: Secondary Analysis of a Randomized, Double-Blind, Placebo-Controlled Trial

Frontiers in Endocrinology

Tadeusz Pietras¹  Joanna Kręczyńska²  Anna Wiktorowska-Owczarek³  Michał Seweryn Karbownik³  Edward Kowalczyk³  Nebojša Stilinović⁴  Magdalena Cybula⁵  Paulina Kwarta⁶ 

[1] Department of Clinical Pharmacology, Medical University of Lodz, Łódź, Poland;Department of Infectious Diseases and Hepatology, Medical University of Lodz, Łódź, Poland;Department of Pharmacology and Toxicology, Medical University of Lodz, Łódź, Poland;Department of Pharmacology, Toxicology and Clinical Pharmacology, University of Novi Sad, Novi Sad, Serbia;Oklahoma Medical Research Foundation, Aging and Metabolism Program, Oklahoma City, OK, United States;Psychiatric Ward for Adolescents, Babinski Specialist Psychiatric Healthcare Center, Łódź, Poland;

关键词: probiotic;    yeast;    Saccharomyces boulardii;    dietary supplementation;    salivary serotonin;    symapathoadrenal markers;   

DOI  :  10.3389/fendo.2021.800023

来源: DOAJ

【 摘 要 】

BackgroundBacterial probiotics are thought to exert a serotonergic effect relevant to their potential antidepressant and pro-cognitive action, but yeast probiotics have not been tested. The aim of the present study was to determine whether 30-day supplementation with Saccharomyces boulardii affects the level of salivary serotonin under psychological stress and identify the factors associated with it.MethodsHealthy medical students were randomized to ingest Saccharomyces boulardii CNCM I-1079 or placebo before a stressful event. Salivary serotonin concentration was assessed before and at the end of supplementation. Moreover, obtained results were compared to psychological, biochemical, physiological and sociodemographic study participants data.ResultsData of thirty-two participants (22.8 ± 1.7 years of age, 16 males) was available for the main analysis. Supplementation with Saccharomyces boulardii decreased salivary serotonin concentration under psychological stress by 3.13 (95% CI 0.20 to 6.07) ng/mL, p = 0.037, as compared to placebo. Salivary serotonin was positively correlated with salivary metanephrine (β = 0.27, 95% CI 0.02 to 0.52, p = 0.031) and pulse rate (β = 0.28, 95% CI 0.05 to 0.50, p = 0.018), but insignificantly with anxiety, depression, eating attitudes and information retrieval.ConclusionsSaccharomyces boulardii CNCM I-1079 may be distinct from bacterial probiotics in its salivary serotonergic effect, which appears positively linked to symapathoadrenal markers. The study requires cautious interpretation, and further investigation.

【 授权许可】

Unknown