Numerical Optimization of an Open-Ended Coaxial Slot Applicator for the Detection and Microwave Ablation of Tumors

Biology

Sabrina Klos¹  Martin Schüßler²  Markus Kochanek²  Carolin Hessinger²  Rolf Jakoby² 

[1] Communications Engineering Lab, Technische Universität Darmstadt, 64289 Darmstadt, Germany;Institute for Microwave Engineering and Photonics, Technische Universität Darmstadt, Merckstr. 25, 64283 Darmstadt, Germany;

关键词: microwave ablation;    microwave applicator;    multiobjective optimization;   

DOI  :  10.3390/biology10090914

来源: DOAJ

【 摘 要 】

A multiobjective optimization method for a dual-mode microwave applicator is proposed. Dual-modality means that microwaves are used apart from the treatment, and also for the monitoring of the microwave ablation intervention. (1) The use of computational models to develop and improve microwave ablation applicator geometries is essential for further advances in this field. (2) Numerical electromagnetic–thermal coupled simulation models are used to analyze the performance of the dual-mode applicator in liver tissue; the sensitivity evaluation of the dual-mode applicator’s sensing mode constrains the set of optimal solutions. (3) Three Pareto-optimal design parameter sets are derived that are optimal in terms of applicator efficiency as well as volume and sphericity of the ablation zone. The resulting designs of the dual-mode applicator provide a suitable sensitivity to distinguish between healthy and tumorous liver tissue. (4) The optimized designs are presented and numerically characterized. An improvement on the performance of previously proposed dual-mode applicator designs is achieved. The multiphysical simulation model of electromagnetic and thermal properties of the applicator is applicable for future comprehensive design procedures.

【 授权许可】

Unknown