The Genetic Association of Polycystic Ovary Syndrome and the Risk of Endometrial Cancer: A Mendelian Randomization Study

Frontiers in Endocrinology

Yan Wang²  Yuanzhi Tao³  Yaoyao Zhang³  Shangwei Li³  Hanxiao Chen³  Yihong Yang³  Kemin Cheng⁴  Lang Qin⁵  Wenming Xu⁶  Rui Gao⁷ 

[1] Sichuan Provincial People’s Hospital, Chengdu, China;;Department of Obstetrics and Gynaecology, Sichuan Academy of Medical Sciences &Key Laboratory of Birth Defects and Related Diseases of Women and Children of the Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China;Outpatient Department, West China Second University Hospital, Sichuan University, Chengdu, China;Reproductive Centre, Department of Obstetrics and Gynaecology, West China Second University Hospital, Sichuan University, Chengdu, China;Sichuan University-The Chinese University of Hong Kong (SCU–CUHK) Joint Laboratory for Reproductive Medicine, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China;West China School of Medicine, Sichuan University, Chengdu, China;

关键词: polycystic ovary syndrome;    endometrial cancer;    Mendelian randomization;    GWAS;    SNP;   

DOI  :  10.3389/fendo.2021.756137

来源: DOAJ

【 摘 要 】

The association between polycystic ovary syndrome (PCOS) and endometrial cancer remains unclear. We aimed to investigate the causal association between genetically predicted PCOS and endometrial cancer risk in two ethnic groups through a two-sample Mendelian randomization (MR) approach. Our study includes 13 single nucleotide polymorphisms (SNPs) as instrumental variables (IVs) for PCOS in Europeans, and another 13 SNPs are used as IVs for PCOS in Asians. Outcome data were obtained from the largest published meta-GWAS of European ancestry to date, as well as from the BioBank Japan Project of Asian ancestry. Our study demonstrates that genetically predicted PCOS is not causally associated with the risk of overall endometrial cancer in either Europeans or Asians (odds ratio (OR) = 0.93, 95% confidence interval (CI) = 0.85–1.01, p = 0.09 and OR = 0.98, 95% CI 0.84–1.13, p = 0.75, respectively). Subgroup analyses according to histotype further illustrate that PCOS might not be associated with the risk of either endometrioid endometrial cancer or non-endometrioid endometrial cancer in European ancestry. No pleiotropy is found in our study, and a sensitivity analysis shows similar results. Our results indicate that genetically predicted PCOS might not be associated with the risk of endometrial cancer.

【 授权许可】

Unknown