Seroprevalence of dengue virus among children presenting with febrile illness in some public health facilities in Cameroon

The Pan African Medical Journal

Abel Lissom¹  Jules-Roger Kuiate²  Thibau Flaurant Tchouangueu²  Salomon Bonsi Tchuandom²  Etienne Philemon Atabonkeng²  Christophe Antonio-Nkondjio³  Godwin Nchinda⁴  Jean Olivier Ngono Djang⁵  Assumpta Kechia⁶ 

[1] Department of Animal Biology and Physiology, University of Yaoundé 1, YaounMinistry of Public Health, Yaoundé, Cameroun;Department of Biochemistry, University of Dschang, Cameroon;Laboratoire de Recherche sur le Paludisme, Organisation de Coordination pour la lutte Contre les Endémies en Afrique Centrale (OCEAC), Yaoundé, Cameroun;Laboratory of Microbiology and Immunology, Chantal Biya International Reference Centre for Research and Prevention on HIV/AIDS Yaoundé;Public School of medical Laboratory Technicians, Yaoundé, Cameroon;;

关键词: dengue virus;    children;    febrile illness;    health facilities;    cameroon;   

DOI  :  10.11604/pamj.2018.31.177.16390

来源: DOAJ

【 摘 要 】

INTRODUCTION: A routine diagnosis of dengue virus (DENV) infection is not usually conducted in hospitals. Because symptoms overlap, many potential febrile illnesses due to DENV may be confused for malaria, typhoid or paratyphoid (enteric) fever. The absence of data on DENV exposure rates among children attending health facilities could undermine management of this disease. This study aimed to investigate the seroprevalence of dengue virus infection in children presenting febrile illness in some public health facilities in Cameroon. METHODS: a cross-sectional study was performed in children ≤ 15 years attending seven urban and three semi-urban public hospitals of Cameroon. From each volunteer, 2ml of whole blood was collected and tested for dengue virus IgM, malaria (Pf/Pan antigens) and enteric fever (Typhoid IgM) using rapid diagnostic tests (RDT); in order to allow the healthcare workers to quickly put the positive cases under appropriate treatment. Positive cases of dengue virus infection were confirmed by indirect ELISA. Data analysis were performed using the statistical package for social sciences software, version 22.1. RESULTS: a total of 961 children were enrolled in the study and 492 (51.2%) were infected with at least one of the three pathogens. Overall, DENV IgM seroprevalence among febrile children was 14.4% (138/961). About 390 (40.6%) and 22 (2.3%) had malaria (Pf/Pan Ag) and enteric fever (Typhoid IgM) respectively. Co-infection with dengue virus was found in 51 (5.3%) participants. The dengue virus IgM seroprevalence was higher in Bankim (19.3%), Ntui (18.3%) and Douala (18.2%). CONCLUSION: dengue virus infection seroprevalence appears to be low in children presenting with febrile illness in the studied health centres in Cameroon but call for more attention and research to further characterise the circulating strains of the dengue virus.

【 授权许可】

Unknown