The nanotoxicity investigation of optical nanoparticles to cultured cells in vitro

Toxicology Reports

Jing Li¹  Li Chen¹  Dan Shao¹  Jie Song²  Wenyu Ji³  Qinghui Zeng³ 

[1] Department of Pharmacology, Norman Bethune College of Medicine, Jilin University, Changchun, PR China;Interdisciplinary Nanoscience Center (iNANO), Aarhus University, DK-8000 Aarhus C, Denmark;State Key Laboratory of Luminescence and Applications, Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Sciences, Changchun, PR China;

关键词: Nanotoxicity;    Gold nanospheres;    Gold nanorods;    Silver nanospheres;    Silver triangular nanoplates;    CdTe/CdS quantum dots;    Hela cells;    HepG2 cells;    SRB;   

DOI  :  10.1016/j.toxrep.2014.05.009

来源: DOAJ

【 摘 要 】

Optical nanoparticles (NPs) have the potential to provide new tools for diagnosis and treatment of human diseases, however, their nanotoxicity and biological characteristics are still unclear. Here, we prepared a series of typical NPs (including gold nanospheres, gold nanorods, silver nanopheres, silver triangular nanoplates and quantum dots) with different material and surface chemical modification for nanotoxicity test. Cell proliferation was investigated by SRB assay where the NPs were co-cultured with cancer cells. It was found that NPs’ toxicity was highly correlated to different factors—material selection, physical size/surface area, shape, and surface chemical property, etc. This work has the potential to provide a uniform and systematic information when they are applied as probes in biological and medical fields.

【 授权许可】

Unknown