Resveratrol Inhibits Particulate Matter-Induced Inflammatory Responses in Human Keratinocytes

International Journal of Molecular Sciences

Jung-Im Na¹  Hyun-Sun Lee¹  Hye-Ryung Choi¹  Kyung-Chan Park¹  Chang-Hun Huh¹  Jung-Won Shin¹ 

[1] Department of Dermatology, Bundang Hospital, Seoul National University, Seongnam 13620, Korea;

关键词: air pollution;    aryl hydrocarbon receptor;    oxidative stress;    particulate matter;    resveratrol;    skin inflammation;   

DOI  :  10.3390/ijms21103446

来源: DOAJ

【 摘 要 】

Particulate matter (PM), a major air pollutant, is a complex mixture of solid and liquid particles of various sizes. PM has been demonstrated to cause intracellular inflammation in human keratinocytes, and is associated with various skin disorders, including atopic dermatitis, eczema, and skin aging. Resveratrol is a natural polyphenol with strong antioxidant properties, and its beneficial effects against skin changes due to PM remain elusive. Therefore, in the present study, we investigated the effect of resveratrol on PM-induced skin inflammation and attempted to deduce the molecular mechanisms underlying resveratrol’s effects. We found that resveratrol inhibited PM-induced aryl hydrocarbon receptor activation and reactive oxygen species formation in keratinocytes. It also suppressed the subsequent cellular inflammatory response by inhibiting mitogen-activated protein kinase activation. Consequentially, resveratrol reduced PM-induced cyclooxygenase-2/prostaglandin E2 and proinflammatory cytokine expression, including that of matrix metalloproteinase (MMP)-1, MMP-9, and interleukin-8, all of which are known to be central mediators of various inflammatory conditions and aging. In conclusion, resveratrol inhibits the PM-induced inflammatory response in human keratinocytes, and we suggest that resveratrol may have potential for preventing air pollution-related skin problems.

【 授权许可】

Unknown