Neuromuscular Complications of SARS-CoV-2 and Other Viral Infections

Frontiers in Neurology

Honglin Luo¹  Gerald Pfeffer²  Renée N. Douville³  Kerri L. Schellenberg⁴  Sarah Jacob⁵  Ronak Kapadia⁵  Tyler Soule⁵ 

[1] Centre for Heart and Lung Innovation, Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada;Department of Medical Genetics, Alberta Child Health Research Institute, University of Calgary, Calgary, AB, Canada;Division of Neurodegenerative Disorders, Department of Biology, Albrechtsen St. Boniface Research Centre, University of Winnipeg, Winnipeg, MB, Canada;Division of Neurology, Department of Medicine, University of Saskatchewan, Saskatoon, SK, Canada;Hotchkiss Brain Institute, Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada;

关键词: COVID-19;    SARS-CoV-2;    neuromuscular disease (NMD);    Guillain-Barre syndrome;    viral disease;    autoimmune disease;   

DOI  :  10.3389/fneur.2022.914411

来源: DOAJ

【 摘 要 】

In this article we review complications to the peripheral nervous system that occur as a consequence of viral infections, with a special focus on complications of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). We discuss neuromuscular complications in three broad categories; the direct consequences of viral infection, autoimmune neuromuscular disorders provoked by viral infections, and chronic neurodegenerative conditions which have been associated with viral infections. We also include discussion of neuromuscular disorders that are treated by immunomodulatory therapies, and how this affects patient susceptibility in the current context of the coronavirus disease 2019 (COVID-19) pandemic. COVID-19 is associated with direct consequences to the peripheral nervous system via presumed direct viral injury (dysgeusia/anosmia, myalgias/rhabdomyolysis, and potentially mononeuritis multiplex) and autoimmunity (Guillain Barré syndrome and variants). It has important implications for people receiving immunomodulatory therapies who may be at greater risk of severe outcomes from COVID-19. Thus far, chronic post-COVID syndromes (a.k.a: long COVID) also include possible involvement of the neuromuscular system. Whether we may observe neuromuscular degenerative conditions in the longer term will be an important question to monitor in future studies.

【 授权许可】

Unknown