Sonographic Measurement of Brainstem Through the Foramen Magnum in Premature Neonates Can Predict Neurodevelopment Outcome?

Frontiers in Neurology

Chiung-Hsi Tien¹  Shyi-Jou Chen¹  Chih-Fen Hu¹  Cheng-Yu Chen² 

[1] Department of Pediatrics, Tri-Service General Hospital, Taipei, Taiwan;Department of Radiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan;National Defense Medical Center, Taipei, Taiwan;

关键词: cranial ultrasound;    trans-foramen-magnum high resolution ultrasound;    preterm;    brainstem;    neurodevelopment;   

DOI  :  10.3389/fneur.2021.770908

来源: DOAJ

【 摘 要 】

Background: To investigate whether serial morphometric measurements of the brainstem using high resolution trans-foramen-magnum ultrasound (US) in premature neonates correlate with neurological outcomes.Methods: Serial brain ultrasound scans were performed in 36 consecutive preterm infants born at <34 weeks of gestation from birth until term-equivalent age. Two-dimensional brainstem measurements of the pons and medulla oblongata were compared with those in a cohort of 67 healthy full-term newborns. Neurologic assessment of the premature infants was assessed at 5 years of age.Results: Of the 36 preterm infants born between 25 and 34 weeks of gestation, eight had significantly delayed growth profiles in both the pons and medulla and developed neurological sequelae by 5 years of age.Conclusions: Morphometric measurements of the developing brainstem using high resolution trans-foramen-magnum ultrasound (US) may help predict neurological outcome in high-risk neonates, particularly in those who are born extremely premature.

【 授权许可】

Unknown