Co-pathogens in Periodontitis and Inflammatory Bowel Disease

Frontiers in Medicine

Zixuan Zhuang¹  Lei Zhao²  Tao Zhu³  Zhengwen Cai³  Fengshuo Liu³ 

[1] Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu, China;Department of Periodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China;State Key Laboratory of Oral Diseases, West China College of Stomatology, Sichuan University, Chengdu, China;

关键词: periodontitis;    inflammatory bowel disease;    periodontal disease;    bacteria;    microbiota;    intestine;   

DOI  :  10.3389/fmed.2021.723719

来源: DOAJ

【 摘 要 】

Localized inflammatory lesions in one area of the body may affect other distant organs through various modes of transmission thus initiating secondary inflammatory infections. Periodontal disease (PD) and inflammatory bowel disease (IBD) have been shown to coexist. Periodontitis is a multifactorial inflammatory disease, and dental plaque is considered to be the initial risk factor. Individuals with genetic susceptibility are more likely to develop periodontitis when exposed to external stimuli. IBD is affected by host genetics, immunoregulation, daily diet, and the gut microbiota, and its risk factors appear to be shared with those of PD. However, the key etiologies of both diseases remain unclear, thus hindering the exploration of possible links between IBD and PD. Recent studies and systematic reviews have focused on evidence-based statistics of the prevalence and clinical manifestations of both diseases, but discussions of the microbial etiological correlation between periodontitis and intestinal inflammation are scarce. Here, we summarize the potential common pathogenic microorganisms that may serve as bridges between the two diseases. Studies have shown that invasive microorganisms such as Porphyromonas gingivalis, Fusobacterium nucleatum, Klebsiella spp. and Campylobacter spp. play key roles in the comorbidity of PD and IBD.

【 授权许可】

Unknown