Paracetamol misusing to dental pain: a case-report and recommandations for treatment

Journal of Oral Medicine and Oral Surgery

Catherine Jean-Hugues¹  Lan Romain¹  Campana Fabrice²  Lafont Jacinthe³  Debortoli Cyril⁴ 

[1] DDS, PhD Aix Marseille University, APHM, CNRS, EFS, ADES, La Timone, Odontology Department;DDS, PhD Aix Marseille University, APHM, UMR S910, La Timone, Odontology Department;Oral Surgeon, Aix Marseille University, APHM, La Timone, Odontology Department;Oral Surgery Resident, Aix Marseille University, APHM, La Timone, Odontology Department;

关键词: drug overdose;    acetaminophen;    paracetamol;    toothache;    case report;   

DOI  :  10.1051/mbcb/2021042

来源: DOAJ

【 摘 要 】

Introduction: The paracetamol is the most widely used painkiller to dental pain. Patients self-medicating with paracetamol for dental pain had 12.8 more times lead to overdose than patients with other pains. The aim of this work was to propose a standardized management in case of paracetamol overdose from a clinical case report. Observation: A 56-year-old man was referred to the General Emergency Department because he had ingested 32 grams of paracetamol in less than 24 hours due to a dental pain. He was in a state of haemodynamic and hypothermic shock. He was placed on the liver transplant list due to fulminant hepatitis. The dental check-up found juxta-pulpal carious lesions on the four wisdom teeth which were removed before the transplantation. Conclusion: Paracetamol overdose is one of the leading causes of liver failure. The estimated toxic dose was 150 mg/kg/day or about 10 g/day. N-acetylcysteine treatment should be leaded early, between 8 and 10 hours after ingestion. The paracetamol-aminotransferase, as a risk prediction tool, reproductibles methods and biomarkers can identify overdoses and lead to a faster medical care. Information campaigns and warning articles on overdosing risk must be continued to strengthen the prevention message for the population.

【 授权许可】

Unknown