Mild Cognitive Impairment and Mild Dementia: The Role of Ginkgo biloba (EGb 761®)

Pharmaceuticals

Vincenzo Solfrizzi¹  Patrizia Russo²  Federica Marcolongo²  Carolina Muscoli³  Sara Ilari³  Giovanni Scapagnini⁴  PaoloMaria Rossini⁵  Valentina Malafoglia⁶  Guglielmo Zilio⁷  Stefania Proietti⁸  Carlo Tomino⁸ 

[1] Clinica Medica “Frugoni” and Geriatric Medicine-Memory Unit, University of Bari Aldo Moro, 70122 Bari, Italy;Clinical and Molecular Epidemiology, IRCCS San Raffaele Roma, 00166 Rome, Italy;Department of Health Science, Institute of Research for Food Safety & Health (IRC-FSH), University “Magna Graecia” of Catanzaro, 88201 Catanzaro, Italy;Department of Medicine and Health Sciences “V. Tiberio”, University of Molise, 86100 Campobasso, Italy;Department of Neuroscience & Neurorehabilitation, IRCCS San Raffaele Roma, 00163 Rome, Italy;Institute for Research on Pain, ISAL Foundation, Torre Pedrera, 47922 Rimini, Italy;Scientific Department, Schwabe Pharma Italia S.r.l., 39044 Egna, Italy;Scientific Direction, IRCCS San Raffaele Roma, 00166 Rome, Italy;

关键词: mild cognitive impairment (MCI);    mild dementia;    Alzheimer’s disease;    Ginkgo biloba (Egb761^®);    Tebonin;    anti-dementia drugs;   

DOI  :  10.3390/ph14040305

来源: DOAJ

【 摘 要 】

Mild cognitive impairment (MCI) and dementia are clinically prevalent in the elderly. There is a high risk of cognitive decline in patients diagnosed with MCI or dementia. This review describes the effectiveness of Ginkgo biloba leaf special extract EGb 761^® for the treatment of dementia syndromes and EGb 761^® combination therapy with other medications for symptomatic dementia. This drug has shown convincing results, improving cognitive function, neuropsychiatric symptoms and consequent reduction of caregiver stress and maintenance of autonomy in patients with age-related cognitive decline, MCI and mild to moderate dementia. Currently, there is little evidence to support the combination therapy with anti-dementia drugs and, therefore, more evidence is needed to evaluate the role of EGb 761^® in mixed therapy.

【 授权许可】

Unknown