Vitamin D deficiency and risk of cardiovascular diseases: a narrative review

Clinical Hypertension

Sahar Ahmed¹  Mustafa Hassan¹  Ghassan Bachuwa¹  Babikir Kheiri¹  Ahmed Abdalla¹  Mohammed Osman¹ 

[1] Department of Internal Medicine, Hurley Medical Center/Michigan State University;

关键词: Vitamin D;    Cholecalciferol;    Cardiovascular disease;    Hypertension;    Blood pressure;    Coronary artery disease;   

DOI  :  10.1186/s40885-018-0094-4

来源: DOAJ

【 摘 要 】

Abstract Vitamin D, a fat-soluble prohormone, has wide-ranging roles in the regulation of many physiological processes through their interactions with the vitamin D receptors (VDR). It plays a major role in bones and calcium metabolism. Vitamin D deficiency is not uncommon and it has been associated with many health-related issues, including skeletal and non-skeletal complications. The association of low vitamin D and cardiovascular diseases and risk factors has been explored in both animal and human studies. However, studies and trials on the effect of vitamin D supplementation on cardiovascular risk factors and hypertension are conflicting with inconsistent results. Therefore, large, well-powered randomized controlled trials are warranted. If successful, supplementation with easy and low-cost vitamin D can impact our health positively. Here, we summarized the evidence for the association of vitamin D, cardiovascular diseases and risk factors, including coronary artery diseases, stroke, and hypertension, and mortality, with special consideration to resistant hypertension.

【 授权许可】

Unknown