Elevated plasminogen activators are associated with hematoma progression in spontaneous intracerebral hemorrhage

Brain Hemorrhages

Michael Desborough¹  Kamini Rakkar²  Zhe Kang Law³  Ulvi Bayraktutan³  Philip M. Bath³  Nikola Sprigg³ 

[1] Department of Medicine, National University of Malaysia, Malaysia;Haemophilia and Thrombosis Centre, St Thomas' Hospital, London, UK;Stroke, Division of Clinical Neuroscience, University of Nottingham, UK;

关键词: Intracerebral hemorrhage;    Hematoma growth;    Fibrinolysis;    Plasminogen activators;    Clinical trial;    Plasma biomarker;   

DOI  :  

来源: DOAJ

【 摘 要 】

Endogenous fibrinolysis might lead to hematoma progression in spontaneous intracerebral hemorrhage (ICH). We studied plasma biomarkers of fibrinolysis and hemostasis in twenty-two patients with ICH and nine healthy controls (HC) in a single-center study. Patients with ICH had significantly higher D-dimer and plasmin-alpha-2-antiplasmin complexes compared to HC. At baseline, patients with hematoma progression had higher urokinase-type plasminogen activator (uPA) and tissue-type plasminogen activator (tPA) and lower plasminogen levels, compared to those with no progression. 24-hour and day-7 matrix metalloproteinase-9 (MMP-9) was significantly increased in patients with hematoma progression.

【 授权许可】

Unknown