Newly Developed Prodrugs and Prodrugs in Development; an Insight of the Recent Years

Molecules

Abderrahman Najjar¹  Anas Najjar²  Rafik Karaman³ 

[1] Pharmaceutical Chemistry, Al-Quds University, Jerusalem P.O. Box 20002, Palestine;;Faculty of Pharmacy, Department of Bioorganic &Institute of Pathology, Rabin Medical Centre, PetachTikva 49100, Israel;

关键词: act-281959;    anavex 2-73;    baloxavir marboxil;    clinical trial;    evofosfamide;    fostemsavir;    ixazomib;    pretomanid;    prodrug;    selexipag;   

DOI  :  10.3390/molecules25040884

来源: DOAJ

【 摘 要 】

Background: The design and development of prodrugs is the most common and effective strategy to overcome pharmacokinetic and pharmacodynamic drawbacks of active drugs. A respected number of prodrugs have been reached the drugs market throughout history and the recent years have witnessed a significant increase in the use of prodrugs as a replacement of their parent drugs for an efficient treatment of various ailment. Methods: A Scan conducted to find recent approved prodrugs and prodrugs in development. Results: Selected prodrugs were reported and categorized in accordance to their target systems. Conclusions: the prodrug approach has shown many successes and still remains a viable and effective approach to deliver new active agents. This conclusion is supported by the recent approved prodrugs and the scan of clinical trials conducted between 2013−2018.

【 授权许可】

Unknown