Non-Invasive Biomarkers for Early Detection of Breast Cancer

Cancers

Lai-Ming Ching¹  Xiaojia Wang²  Wen-Ming Cao²  Zhimin Fan³  Xin Guan⁴  Jiawei Li⁴  Dong-Xu Liu⁴  Yan Li⁴ 

[1] Auckland Cancer Society Research Centre, Faculty of Medical and Health Sciences, University of Auckland, Auckland 1023, New Zealand;Department of Breast Medical Oncology, Cancer Hospital of the University of Chinese Academy of Sciences, Zhejiang Cancer Hospital & Institute of Cancer and Basic Medicine (IBMC), Chinese Academy of Sciences, Hangzhou 310022, China;Department of Breast Surgery, the First Hospital of Jilin University, Jilin University, Changchun 130021, China;The Centre for Biomedical and Chemical Sciences, School of Science, Faculty of Health and Environmental Sciences, Auckland University of Technology, Auckland 1010, New Zealand;

关键词: breast cancer;    biomarker;    diagnosis;    detection;    blood;    body fluid;   

DOI  :  10.3390/cancers12102767

来源: DOAJ

【 摘 要 】

Breast cancer is the most common cancer in women worldwide. Accurate early diagnosis of breast cancer is critical in the management of the disease. Although mammogram screening has been widely used for breast cancer screening, high false-positive and false-negative rates and radiation from mammography have always been a concern. Over the last 20 years, the emergence of “omics” strategies has resulted in significant advances in the search for non-invasive biomarkers for breast cancer diagnosis at an early stage. Circulating carcinoma antigens, circulating tumor cells, circulating cell-free tumor nucleic acids (DNA or RNA), circulating microRNAs, and circulating extracellular vesicles in the peripheral blood, nipple aspirate fluid, sweat, urine, and tears, as well as volatile organic compounds in the breath, have emerged as potential non-invasive diagnostic biomarkers to supplement current clinical approaches to earlier detection of breast cancer. In this review, we summarize the current progress of research in these areas.

【 授权许可】

Unknown