Endoplasmic reticulum stress in the pathogenesis of age-related macular degeneration

Guoji Yanke Zazhi

Xia Liu¹  Yan Wang²  Chen Chen³  Yu-Ling Ren⁴  Hua-Wei Jiang⁵ 

[1] Department of Ophthalmology, Fourth Affiliated Hospital of Kunming Medical University;Department of Ophthalmology, the Second People's Hospital of Yunnan Province;The Ocular Disease Clinical Medicine Center of Yunnan Province;The Ocular Disease and Clinical Medicine Research Center of Yunnan Province;Yunnan Eye Institute;

关键词: age-related macular degeneration;    endoplasmic reticulum stress;    unfolded protein response;    retinal pigment epithelium cells;    apoptosis;   

DOI  :  10.3980/j.issn.1672-5123.2022.2.14

来源: DOAJ

【 摘 要 】

Age-related macular degeneration(ARMD)is a main cause of irreversible visual impairment in the elderly. The major pathological features are drusen formation, macular pigment disorder, geographic atrophy and abnormal neovascularization. Retinal pigment epithelium(RPE)function is impaired in ARMD. Endoplasmic reticulum(ER)is an organelle in eukaryotes responsible for protein synthesis, modification, integration and quality control. ER also participates in the maintenance of calcium homeostasis and lipid biosynthesis. Stimuli from the external and internal environment may trigger ER stress and therefore activate the intracellular signal transduction pathway-the unfolded protein response(UPR), to restore cell homeostasis. However, prolonged ER stress may lead to apoptosis. The pathogenesis of ARMD has not been fully elucidated, nevertheless, compelling evidence demonstrates that ER stress is involved. In this article, we summarize recent advances in UPR pathways, as well as the role of ER stress in the physiological function of RPE and in the pathogenesis of ARMD.

【 授权许可】

Unknown