Airway Microbiota-Host Interactions Regulate Secretory Leukocyte Protease Inhibitor Levels and Influence Allergic Airway Inflammation

Cell Reports

Ryan T. McDonough¹  Natalia Jaeger¹  Naomi G. Wilson¹  Michael A. Lint¹  Ariel Hernandez-Leyva¹  Anne L. Rosen¹  Andrew L. Kau¹  Leonard B. Bacharier²  Emilie V. Russler-Germain³  Chyi-Song Hsieh³  Jiani N. Chai³ 

[1] Division of Allergy and Immunology, Department of Medicine and Center for Women’s Infectious Disease Research, Washington University School of Medicine, St. Louis, MO 63110, USA;Division of Allergy, Immunology and Pulmonary Medicine, Department of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110, USA;Division of Rheumatology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA;

关键词: asthma;    Bordetella pseudohinzii;    airway microbiota;    airway microbiome;    secretory leukocyte protease inhibitor (SLPI);    allergic airway inflammation;   

DOI  :  

来源: DOAJ

【 摘 要 】

Summary: Homeostatic mucosal immune responses are fine-tuned by naturally evolved interactions with native microbes, and integrating these relationships into experimental models can provide new insights into human diseases. Here, we leverage a murine-adapted airway microbe, Bordetella pseudohinzii (Bph), to investigate how chronic colonization impacts mucosal immunity and the development of allergic airway inflammation (AAI). Colonization with Bph induces the differentiation of interleukin-17A (IL-17A)-secreting T-helper cells that aid in controlling bacterial abundance. Bph colonization protects from AAI and is associated with increased production of secretory leukocyte protease inhibitor (SLPI), an antimicrobial peptide with anti-inflammatory properties. These findings are additionally supported by clinical data showing that higher levels of upper respiratory SLPI correlate both with greater asthma control and the presence of Haemophilus, a bacterial genus associated with AAI. We propose that SLPI could be used as a biomarker of beneficial host-commensal relationships in the airway.

【 授权许可】

Unknown