期刊论文详细信息
International Journal of Biomedicine | |
Role of Mutations in NOD2/CARD15, ATG16L1, and IRGM in the Pathogenesis of Crohn’s Disease | |
Dmitry N. Andreev1  Igor’ V. Maev2  | |
[1] Moscow, Russian Federation;Moscow State University of Medicine and Dentistry named after A.I. Evdokimov; | |
关键词: innate immunity; autophagy; xenophagy; microbiota; NOD2/CARD15; ATG16L1; Crohn's disease; innate immunity; autophagy; xenophagy; microbiota; NOD2/CARD15; ATG16L1; | |
DOI : | |
来源: DOAJ |
【 摘 要 】
This review article summarizes the issues concerning the pathogenesis of Crohn’s disease (CD) based on the results of large-scale genome-wide association studies. The role of defects in innate immunity associated with mutations in specific genes such as those regulating bacterial pattern recognition (NOD2/CARD15) and autophagy/xenophagy (ATG16L1 and IRGM) in CD is also discussed. Basic pathogenetic hypotheses that aim to interpret the association between specific gene mutations and CD development are presented.
【 授权许可】
Unknown