Role of Mutations in NOD2/CARD15, ATG16L1, and IRGM in the Pathogenesis of Crohn’s Disease

International Journal of Biomedicine

Dmitry N. Andreev¹  Igor’ V. Maev² 

[1] Moscow, Russian Federation;Moscow State University of Medicine and Dentistry named after A.I. Evdokimov;

关键词: innate immunity;    autophagy;    xenophagy;    microbiota;    NOD2/CARD15;    ATG16L1;    Crohn's disease;    innate immunity;    autophagy;    xenophagy;    microbiota;    NOD2/CARD15;    ATG16L1;   

DOI  :  

来源: DOAJ

【 摘 要 】

This review article summarizes the issues concerning the pathogenesis of Crohn’s disease (CD) based on the results of large-scale genome-wide association studies. The role of defects in innate immunity associated with mutations in specific genes such as those regulating bacterial pattern recognition (NOD2/CARD15) and autophagy/xenophagy (ATG16L1 and IRGM) in CD is also discussed. Basic pathogenetic hypotheses that aim to interpret the association between specific gene mutations and CD development are presented.

【 授权许可】

Unknown