BMC Medicine | |
Genetic, environmental and stochastic factors in monozygotic twin discordance with a focus on epigenetic differences | |
关键词: Twins; Discordance; Epigenetics; Heritability; Environment; | |
DOI : 10.1186/1741-7015-10-93 | |
来源: DOAJ |
【 摘 要 】
Abstract
Genetic-epidemiological studies on monozygotic (MZ) twins have been used for decades to tease out the relative contributions of genes and the environment to a trait. Phenotypic discordance in MZ twins has traditionally been ascribed to non-shared environmental factors acting after birth, however recent data indicate that this explanation is far too simple. In this paper, we review other reasons for discordance, including differences in the
【 授权许可】
Unknown