Emerging Insights into the Function of Kinesin-8 Proteins in Microtubule Length Regulation

Biomolecules

AmberL. Yount¹  ClaireE. Walczak²  Mark Hazelbaker²  Sanjay Shrestha² 

[1] Department of Molecular and Cellular Biochemistry, Indiana University, Bloomington, IN 47405, USA;Medical Sciences Program, Indiana University, Bloomington, IN 47405, USA;

关键词: microtubule dynamics;    mitosis;    spindle;    molecular motor protein;   

DOI  :  10.3390/biom9010001

来源: DOAJ

【 摘 要 】

Proper regulation of microtubules (MTs) is critical for the execution of diverse cellular processes, including mitotic spindle assembly and chromosome segregation. There are a multitude of cellular factors that regulate the dynamicity of MTs and play critical roles in mitosis. Members of the Kinesin-8 family of motor proteins act as MT-destabilizing factors to control MT length in a spatially and temporally regulated manner. In this review, we focus on recent advances in our understanding of the structure and function of the Kinesin-8 motor domain, and the emerging contributions of the C-terminal tail of Kinesin-8 proteins to regulate motor activity and localization.

【 授权许可】

Unknown