Cyclin C: A new responser for chemosensitivity in cancer

Clinical and Translational Medicine

Zhaohui Gong¹  Xiaofeng Jin¹  Chengwei Zhou²  Shuai Fang² 

[1] Department of Biochemistry and Molecular Biology Ningbo University School of Medicine Ningbo China;Department of Thoracic Surgery The Affiliated Hospital of Medical School of Ningbo University Ningbo China;

关键词: cyclin C;    chemotherapy;    gastric cancer;   

DOI  :  10.1002/ctm2.833

来源: DOAJ

【 摘 要 】

Abstract The resistance to cisplatin‐based chemotherapy is a common cause of poor prognosis in cancer patients. Cisplatin stimulation causes cyclin C translocating to mitochondria, and in turn induces mitochondrial fission. However, little is known about the role of cyclin C in mitochondrial dysfunction in cancer cells challenged with cisplatin. In the present commentary, we bring to the attention of readers the recent report by Jiang et al which revealed the importance of ubiquitylation and translocation of cyclin C in gastric cancer cells in response to cisplatin stimulation for mitochondrial stability. This finding provides new insights into exploring the novel mechanisms of chemoresistance and developing the new chemotherapy synergistic agents in the era of precision oncology.

【 授权许可】

Unknown