Large granular lymphocytic leukemia cured by allogeneic stem cell transplant: a case report

Journal of Medical Case Reports

Maher Abdul-Hay¹  Edward Carey¹  Nicholas Ward² 

[1]Department of Internal Medicine, New York University Grossman School of Medicine

[2]Department of Pathology, New York University Grossman School of Medicine

关键词: LGL;    Allogeneic stem cell transplant;    Neutropenia;    GVHD;   

DOI  :  10.1186/s13256-022-03447-y

来源: DOAJ

【 摘 要 】

Abstract Background Large granular lymphocytic leukemia is a rare lymphocytic neoplasm that can pose a treatment challenge in patients with severe neutropenia in whom conventional therapies fail. We report one of the first cases in which allogeneic stem cell therapy was used as treatment for large granular lymphocytic leukemia. We report and discuss the case of a 42-year-old white Caucasian female who, despite multiple therapies including methotrexate, cyclophosphamide, prednisone, cyclosporine, and pentostatin, continued to show severe neutropenia and recurrent infections. The patient was treated successfully and cured by allogeneic stem cell transplant without any major complications. Conclusions The significant importance of this case report is the introduction of a new treatment algorithm for challenging cases of T-cell large granular lymphocytic leukemia in which standard care fails. We hope that this case report will raise awareness of the potential benefits of allogeneic stem cell transplant in the treatment of aggressive forms of T-cell large granular lymphocytic leukemia.

【 授权许可】

Unknown