High pseudotumor cerebri incidence in tretinoin and arsenic treated acute promyelocytic leukemia and the role of topiramate after acetazolamide failure

Leukemia Research Reports

Morgan B. Smith¹  Craig W. Freyer¹  Eunice S. Wang²  Elizabeth A. Griffiths²  James E. Thompson²  Meir Wetzler² 

[1] Department of Pharmacy, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, United States;Leukemia Section, Department of Medicine, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, United States;

关键词: Tretinoin;    All-trans retinoic acid;    Pseudotumor cerebri;    Topiramate;    Arsenic trioxide;   

DOI  :  10.1016/j.lrr.2014.07.001

来源: DOAJ

【 摘 要 】

Dual differentiation therapy with arsenic trioxide and tretinoin (all-trans-retinoic acid; ATRA) for the management of low and intermediate risk acute promyelocytic leukemia has recently been recommended by the National Comprehensive Cancer Network. Some less common toxicities of the combination may have yet to be fully realized. Of ten patients we have treated thus far, five (50%) have developed pseudotumor cerebri. In one patient, temporary discontinuation of ATRA and initiation of acetazolamide controlled symptoms. In four patients, topiramate was substituted for acetazolamide to relieve symptoms and allow ATRA dose re-escalation. We conclude that providers should monitor for pseudotumor cerebri and consider topiramate if acetazolamide fails.

【 授权许可】

Unknown