Nucleophosmin 1 Mutations in Acute Myeloid Leukemia

Genes

Rashmi Kanagal-Shamanna¹  GhayasC. Issa²  NicholasJ. Short²  Jabra Zarka² 

[1] Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA;Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA;

关键词: AML;    nucleophosmin (NPM1);    gene expression;    targeted therapies;   

DOI  :  10.3390/genes11060649

来源: DOAJ

【 摘 要 】

Nucleophosmin (NPM1) is a ubiquitously expressed nucleolar protein involved in ribosome biogenesis, the maintenance of genomic integrity and the regulation of the ARF-p53 tumor-suppressor pathway among multiple other functions. Mutations in the corresponding gene cause a cytoplasmic dislocation of the NPM1 protein. These mutations are unique to acute myeloid leukemia (AML), a disease characterized by clonal expansion, impaired differentiation and the proliferation of myeloid cells in the bone marrow. Despite our improved understanding of NPM1 mutations and their consequences, the underlying leukemia pathogenesis is still unclear. Recent studies that focused on dysregulated gene expression in AML with mutated NPM1 have shed more light into these mechanisms. In this article, we review the current evidence on normal functions of NPM1 and aberrant functioning in AML, and highlight investigational strategies targeting these mutations.

【 授权许可】

Unknown