The effects of zinc deficiency on homeostasis of twelve minerals and trace elements in the serum, feces, urine and liver of rats

Nutrition & Metabolism

Fan Wang¹  Xiaohan Sun²  Zixiang Li³  Lina Fan³  Jiali Zhao³  Yongzhi Sun³  Qingli Yu³  Maoqing Wang³  Yanfeng Chen⁴  Lan Zhao⁴ 

[1] Department of Epidemiology, School of Public Health, Harbin Medical University;Department of Pediatrics, The Second Affiliated Hospital of Harbin Medical University, Harbin Medical University;National Key Disciplines of Nutrition and Food Hygiene, Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University;Public Health Inspection and Testing Institute, Heilongjiang Provincial Center for Disease Control and Prevention;

关键词: Zinc deficiency;    ICP-MS;    Minerals;    Trace elements;    Rat;   

DOI  :  10.1186/s12986-019-0395-y

来源: DOAJ

【 摘 要 】

Abstract Background Zinc deficiency can change the concentrations of minerals and trace elements in the body. However, previous studies still had many limitations. Objective To reveal the effects of zinc deficiency on homeostasis of 16 minerals and trace elements. Methods Forty-five rats were divided randomly into three groups: normal zinc diet (30 mg/kg), low zinc diet (10 mg/kg), and pair-fed diet(30 mg/kg). The concentrations of 16 minerals and trace elements in serum, feces, urine, and liver were measured by inductively coupled plasma mass spectrometry. The excretion of 16 elements in urine and feces were calculated and compared. Results Zinc-deficient rats exhibited significant changes in up to 12 minerals and trace elements. The low zinc diet induced decreased excretion of zinc and concentrations of zinc in serum, feces, urine, and liver. Zinc deficiency increased feces concentrations of Mg, Cu, Se, K, Ag, Fe and Mn; decreased the concentrations of Mg, Cu, Se, K in liver and urine, and a diminished amount of Ag was observed in serum. Decreased urinary concentrations of Zn Ca, Mg, Cu, Se, K, Na, As and Cr, suggested that zinc-deficient rats increased the 9 elements’ renal reabsorption. Decreased concentrations of Ca in liver, urine, and feces, decreased excretion in urine and feces and increased serum total Ca suggested that zinc deficiency increased the redistribution of Ca in serum or other tissues. Zinc deficiency increased excretion of Cu, Se, Fe; and decreased the excretion of other 8 elements except for Ag. Conclusions Zinc deficiency changed the excretion, reabsorption and redistribution of 12 minerals and trace elements in rats. Our findings are the first to show that zinc deficiency alters the concentrations of Ag, Cr, and As. Graphical abstract

【 授权许可】

Unknown