Radiomics/Radiogenomics in Lung Cancer: Basic Principles and Initial Clinical Results

Cancers

Anastasios Gaitanis¹  Nikolaos Papanikolaou²  Athanasios K. Anagnostopoulos³  Achilles N. Chatziioannou⁴  Dimitris Thanos⁵  Emmanouil I. Athanasiadis⁵  Sofia N. Chatziioannou⁶  Konstantinos N. Syrigos⁷  Ioannis Gkiozos⁷ 

[1] Clinical and Translational Research, Center of Experimental Surgery, Biomedical Research Foundation of the Academy of Athens (BRFAA), 11527 Athens, Greece;Computational Clinical Imaging Group, Centre for the Unknown, Champalimaud Foundation, 1400-038 Lisbon, Portugal;Division of Biotechnology, Center of Systems Biology, Biomedical Research Foundation of the Academy of Athens (BRFAA), 11525 Athens, Greece;First Department of Radiology, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece;Greek Genome Centre, Biomedical Research Foundation of the Academy of Athens (BRFAA), 11527 Athens, Greece;Nuclear Medicine Division, Biomedical Research Foundation of the Academy of Athens (BRFAA), 11527 Athens, Greece;Third Department of Internal Medicine, “Sotiria” Hospital, National and Kapodistrian University of Athens, 11527 Athens, Greece;

关键词: radiogenomics;    lung cancer;    radiomics;    learning algorithms;    image science;    review;   

DOI  :  10.3390/cancers14071657

来源: DOAJ

【 摘 要 】

Lung cancer is the leading cause of cancer-related deaths worldwide, and elucidation of its complicated pathobiology has been traditionally targeted by studies incorporating genomic as well other high-throughput approaches. Recently, a collection of methods used for cancer imaging, supplemented by quantitative aspects leading towards imaging biomarker assessment termed “radiomics”, has introduced a novel dimension in cancer research. Integration of genomics and radiomics approaches, where identifying the biological basis of imaging phenotypes is feasible due to the establishment of associations between molecular features at the genomic–transcriptomic–proteomic level and radiological features, has recently emerged termed radiogenomics. This review article aims to briefly describe the main aspects of radiogenomics, while discussing its basic limitations related to lung cancer clinical applications for clinicians, researchers and patients.

【 授权许可】

Unknown