Time‐ and Dose‐Dependent Association of Statin Use With Risk of Clinically Relevant New‐Onset Diabetes Mellitus in Primary Prevention: A Nationwide Observational Cohort Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease

Songhee Cho¹  Yun Jung Kim¹  Shin Hee Kang¹  Min Jung Ko¹  Ae Jeong Jo¹  Sung‐Cheol Yun²  Duk‐Woo Park³  Woo Je Lee⁴  Cheol‐Young Park⁵  Sang‐Ho Jo⁶ 

[1] Division for Healthcare Technology Assessment Research National Evidence‐based Healthcare Collaborating Agency (NECA) Seoul Korea;Division of Biostatistics Asan Medical Center University of Ulsan College of Medicine Seoul Korea;Division of Cardiology Asan Medical Center University of Ulsan College of Medicine Seoul Korea;Division of Endocrinology and Metabolism Asan Medical Center University of Ulsan College of Medicine Seoul Korea;Division of Endocrinology and Metabolism Department of Internal Medicine Kangbuk Samsung Hospital Sungkyunkwan University School of Medicine Seoul Korea;Pyeongchon Sacred Heart Hospital Hallym University Anyang South Korea;

关键词: diabetes mellitus;    hypercholesterolemia;    statin;   

DOI  :  10.1161/JAHA.118.011320

来源: DOAJ

【 摘 要 】

Background Given that statins are increasingly being used for primary‐prevention, the public concerns regarding the risk of new‐onset diabetes mellitus associated with statin use may be an issue. Methods and Results Using healthcare data from the national health insurance examinees, our study comprised a cohort of adults aged ≥40 years with hypercholesterolemia who would be eligible for statin therapy for primary prevention from 2005 to 2012. The primary outcome was the occurrence of clinically relevant new‐onset diabetes mellitus requiring medical therapy. Among 2 162 119 adults with hypercholesterolemia who might be eligible for statin therapy, 638 625 (29.5%) ever used statins and 1 523 494 (70.5%) never used statins. In the propensity‐matched cohort of 518 491 pairs, during mean follow‐up of 3.9 years, being an ever‐user of statin was significantly associated with diabetes mellitus risk compared with being a never‐user of statin (13.4 versus 6.9 per 1000 person‐years; adjusted hazard ratio [HR], 1.88; 95% CI, 1.85–1.93). With increasing duration of statin use, the risk of diabetes mellitus was proportionally increased (HR 1.25 <1 year, HR 2.22 for 1–2 years, and HR 2.62 >2 years). An excess risk of diabetes mellitus was also associated with a higher intensity (HR 1.75 for low‐to‐moderate potency and HR 2.31 for high potency) and a cumulative dosing of statin (HR 1.06 for low‐tertile, HR 1.74 for middle‐tertile, and HR 2.52 for high‐tertile of defined‐daily‐disease). Conclusions In patients receiving statin therapy for primary prevention, there was a time‐ and dose‐dependent association of statin use with an increasing risk of new‐onset diabetes mellitus.

【 授权许可】

Unknown