Gaseous sulfur trioxide induced controllable sulfonation promoting biomineralization and osseointegration of polyetheretherketone implants

Bioactive Materials

Kaili Lin¹  Zixue Jiao²  Peibiao Zhang³  Qinyi Liu⁴  Teng Wan⁵  Min Guo⁵  Yizao Wan⁵  Zongliang Wang⁵ 

[1] Corresponding author.;Department of Orthopaedics, The Second Hospital, Jilin University, Changchun, 130041, PR China;;Department of Oral &Institute of Advanced Materials, East China Jiaotong University, Nanchang, 330013, PR China;Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, PR China;

关键词: Polyetheretherketone;    Sulfonation;    Micro-topology;    Mechanical strength;    Osteointegration;   

DOI  :  

来源: DOAJ

【 摘 要 】

Fabricating a desired porous structure on the surface of biomedical polyetheretherketone (PEEK) implants for enhancing biological functions is crucial and difficult due to its inherent chemical inertness. In this study, a porous surface of PEEK implants was fabricated by controllable sulfonation using gaseous sulfur trioxide (SO3) for different time (5, 15, 30, 60 and 90 min). Micro-topological structure was generated on the surface of sulfonated PEEK implants preserving original mechanical properties. The protein absorption capacity and apatite forming ability was thus improved by the morphological and elemental change with higher degree of sulfonation. In combination of the appropriate micromorphology and bioactive sulfonate components, the cell adhesion, migration, proliferation and extracellular matrix secretion were obviously enhanced by the SPEEK-15 samples which were sulfonated for 15 min. Finding from this study revealed that controllable sulfonation by gaseous SO3 would be an extraordinarily strategy for improving osseointegration of PEEK implants by adjusting the microstructure and chemical composition while maintaining excellent mechanical properties.

【 授权许可】

Unknown