Non-Coding RNAs: Novel Players in Insulin Resistance and Related Diseases

International Journal of Molecular Sciences

Giuseppina Emanuela Grieco¹  Guido Sebastiani¹  Francesco Dotta¹  Laura Nigi¹  Daniela Fignani¹  Caterina Formichi¹  Giada Licata¹  Noemi Brusco¹  Carla Maccora² 

[1] Diabetes Unit, Department of Medicine, Surgery and Neurosciences, University of Siena, 53100 Siena, Italy;Section of Medical Pathophysiology, Food Science and Endocrinology, Department of Experimental Medicine, Sapienza University, 00185 Rome, Italy;

关键词: insulin resistance;    non-coding RNAs;    obesity;    diabetes;    fatty liver disease;   

DOI  :  10.3390/ijms22147716

来源: DOAJ

【 摘 要 】

The rising prevalence of metabolic diseases related to insulin resistance (IR) have stressed the urgent need of accurate and applicable tools for early diagnosis and treatment. In the last decade, non-coding RNAs (ncRNAs) have gained growing interest because of their potential role in IR modulation. NcRNAs are variable-length transcripts which are not translated into proteins but are involved in gene expression regulation. Thanks to their stability and easy detection in biological fluids, ncRNAs have been investigated as promising diagnostic and therapeutic markers in metabolic diseases, such as type 2 diabetes mellitus (T2D), obesity and non-alcoholic fatty liver disease (NAFLD). Here we review the emerging role of ncRNAs in the development of IR and related diseases such as obesity, T2D and NAFLD, and summarize current evidence concerning their potential clinical application.

【 授权许可】

Unknown