The Effects of Lung-Moistening Herbal Medicines on Bleomycin-Induced Pulmonary Fibrosis Mouse Model

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Junmo Ahn¹  Youngmin Bu¹  Kwan-Il Kim¹  Beom-Joon Lee¹  Jae-Woo Park¹  Hee-Jae Jung¹  Hyejin Joo²  Jihye Park³ 

[1] College of Korean Medicine, Kyung Hee University, Seoul 02447, Korea;College of Science in Korean Medicine, Graduate School, Kyung Hee University, Seoul 02447, Korea;Department of Biomedical Science and Technology, Graduate School, Kyung Hee University, Seoul 02447, Korea;

关键词: pulmonary fibrosis;    bleomycin;    herbal medicine;    broncho alveolar lavage fluid;    inflammation;   

DOI  :  10.3390/pr8010102

来源: DOAJ

【 摘 要 】

In traditional medicine, lung-moistening herbal medicines (LMHM) are regarded as a major option for treating symptoms of pulmonary fibrosis (PF) including dry cough and dyspnea. As PF agents are being applied to the development of lung cancer agents, PF and lung cancer are reported to have high pathological and pharmacological relationships. This study was proposed to identify candidates for the treatment of PF via investigating the effect of LMHM on PF mouse model. PF was induced by intratracheal instillation of bleomycin. Six water extracts of LMHM such as Farfarae Flos (FAF), Trichosanthis Semen (TRS), Lilii Bulbus (LIB), Adenophorae Radix (ADR), Asteris Radix (ASR), and Scrophulariae Radix (SCR) were prepared and administered (300 mg/kg) orally for 10 days after induction. The changes in body weight, histopathology, and immune cell of bronchoalveolar lavage fluid (BALF) were investigated. Among those, LIB and ADR significantly decreased the deposition of collagen and septal thickness of alveolar and terminal bronchiole. Moreover, SCR, TRS, LIB, and ADR decreased total cells, macrophages, and lymphocytes in BALF. Taken together, ADR and LIB could be the candidates to reduce PF. Further studies on their effects at different doses and analysis of their underlying molecular mechanisms are needed.

【 授权许可】

Unknown