Theoretical analysis of effects of transcranial magneto-acoustical stimulation on neuronal spike-frequency adaptation

BMC Neuroscience

Song Zhao¹  Xiaoyuan Luo²  Yi Yuan²  Minzhuang Liu³  Dan Liu³ 

[1] Department of Medical Imaging, The Second Hospital of Hebei Medical University;Institute of Electrical Engineering, Yanshan University;Institute of Integrative Medicine, Hebei University of Chinese Medicine;

关键词: Spike-frequency adaptation;    TMAS;    Ermentrout model;   

DOI  :  10.1186/s12868-022-00709-9

来源: DOAJ

【 摘 要 】

Abstract Background Transcranial magneto-acoustical stimulation (TMAS) is a noninvasive technique that has advantages in spatial resolution and penetration depth. It changes the firing properties of neurons through the current generated by focused ultrasound and a static magnetic field. Spike-frequency adaptation is an important dynamic characteristic of neural information processing. Methods To address the effects of TMAS on neural spike-frequency adaptation, this study employs some ultrasound and magnetic field parameters, such as magnetic flux density, ultrasonic intensity, fundamental ultrasonic frequency, modulation frequency, and duty cycle. Using these different ultrasound and magnetic field parameters, membrane potential curves, spike-frequency curves, and adapted onset spike-frequency curves are exhibited and analyzed. Results The results show that spike-frequency adaptation is strongly dependent on ultrasonic intensity and magnetic flux density and is rarely affected by other parameters. However, modulation frequency and duty cycle influence membrane potentials and spike frequencies to some degree. Conclusions This study reveals the mechanism of the effects of TMAS on neural spike-frequency adaptation and serves as theoretical guidance for TMAS experiments.

【 授权许可】

Unknown