The Hippo Pathway in Innate Anti-microbial Immunity and Anti-tumor Immunity

Frontiers in Immunology

Qian Zhang¹  Pinglong Xu¹  Ruyuan Zhou³ 

[1] Protection and Innovation Center for Cell Signaling Network, Life Sciences Institute, Zhejiang University, Hangzhou, China;;MOE Laboratory of Biosystems Homeostasis &Zhejiang Provincial Key Laboratory of Pancreatic Disease, Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China;

关键词: Hippo-YAP signaling;    innate immunity;    anti-tumor immunity;    anti-microbial;    nucleic acid sensing;    antiviral immunity;   

DOI  :  10.3389/fimmu.2020.01473

来源: DOAJ

【 摘 要 】

The Hippo pathway responds to diverse environmental cues and plays key roles in cell fate determination, tissue homeostasis, and organ regeneration. Aberrant Hippo signaling, on the other hand, has frequently been implicated in diversified pathologies such as cancer and immune dysfunction. Here, we summarize the recent but rapid progress in understanding the involvement of the Hippo pathway in innate immunity, with a special focus on the intrinsic mechanisms and mutual interactions between Hippo-YAP signaling and the innate immune response and its physiological impacts on anti-microbial immunity and anti-tumor immunity. Moving forward, we believe that systematic investigations under the physiological setting are needed to draw a clearer picture of the actions of Hippo in innate immunity.

【 授权许可】

Unknown