Relationship Between Urinary 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanol and Lung Cancer Risk in the General Population: A Community-Based Prospective Cohort Study

Frontiers in Oncology

Jin-Kyoung Oh¹  Min Kyung Lim¹  Do-Hoon Lee²  Eunjung Park³  Eun Young Park³ 

[1] Department of Cancer Control and Population Health, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang-si, South Korea;Department of Laboratory Medicine, National Cancer Center, Goyang-si, South Korea;Division of Cancer Prevention and Early Detection, National Cancer Control Institute, National Cancer Center, Goyang-si, South Korea;

关键词: smoking;    4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK);    4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL);    lung cancer;    biomarker;   

DOI  :  10.3389/fonc.2021.611674

来源: DOAJ

【 摘 要 】

No published studies have prospectively evaluated the association between urinary 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) levels and lung cancer risk in the general population. Here, we conducted a prospective community-based cohort study in the Republic of Korea to evaluate the relationship between urinary NNAL levels and lung cancer risk using prediagnostic urine samples. This prospective cohort study was based on the Korean National Cancer Center Community Cohort. During the follow-up period, 173 primary lung cancer cases were identified. Total urinary NNAL levels were measured by liquid chromatography-tandem mass spectrometry, and data were analyzed using multivariable Cox proportional hazards regression models. The risk of lung cancer was significantly increased per unit of natural log-transformed urinary NNAL (HR, 1.27; 95% CI, 1.09–1.48), after adjusting for age, region, entry year into the cohort, education achievement, alcohol consumption status, BMI, smoking status, and urinary cotinine levels. Cox proportional-hazards models with NNAL quartiles also showed positive dose-response relationships with risk of lung cancer. A significantly increased risk of lung cancer was found in the fourth quartile of urinary NNAL levels (HR, 3.27; 95% CI, 1.37–7.79, P for trend < 0.01). After stratification with sex, the significant association remained in only men. Urinary NNAL levels are associated with the risk of lung cancer in the general population, and this association is independent from the quantification of cigarette smoking and nicotine uptake.

【 授权许可】

Unknown