Neoadjuvant Chemotherapy with Taxane and Platinum Followed by Radical Hysterectomy for Stage IB2-IIB Cervical Cancer: Impact of Histology Type on Survival

Journal of Clinical Medicine

Satoshi Yamaguchi¹  Kei Kawana²  Junichi Kodama³  Toru Sugiyama⁴  Tsutomu Tabata⁵  Hideki Tokunaga⁶  Mikio Mikami⁷  Junzo Kigawa⁸  Muneaki Shimada⁸  Koji Matsuo⁹ 

[1] Department of Gynecologic Oncology, Hyogo Cancer Center, Hyogo 673-0021, Japan;Department of Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8654, Japan;Department of Obstetrics and Gynecology, Hiroshima City Hiroshima Citizens Hospital, Hiroshima 730-8518, Japan;Department of Obstetrics and Gynecology, Iwate Medical University, Iwate 020-0023, Japan;Department of Obstetrics and Gynecology, Mie University Hospital, Mie 514-8507, Japan;Department of Obstetrics and Gynecology, Tohoku University, Miyagi 980-8577, Japan;Department of Obstetrics and Gynecology, Tokai University, Kanagawa 259-1193, Japan;Department of Obstetrics and Gynecology, Tottori University, Tottori 683-8504, Japan;Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Southern California, Los Angeles, CA 90089, USA;

关键词: cervical cancer;    neoadjuvant chemotherapy;    radical hysterectomy;    locally advanced;    squamous;    adenocarcinoma;   

DOI  :  10.3390/jcm8020156

来源: DOAJ

【 摘 要 】

The current study examined the histology-specific impact of neoadjuvant chemotherapy (NACT) with a taxane/platinum regimen on survival in women with locally-advanced cervical cancer who underwent radical hysterectomy. This nation-wide retrospective cohort study examined women with clinical stage IB2-IIB cervical cancer who received NACT prior to radical hysterectomy from 2004⁻2008 (n = 684). NACT type (taxane/platinum versus others) was correlated with survival based on histology: 511 squamous versus 173 non-squamous. Taxane/platinum chemotherapy use was more common in non-squamous compared to squamous tumors (53.8% versus 20.7%, P < 0.001). In both histology types, the taxane/platinum regimen was more frequently utilized over time (both, P < 0.01). Among squamous tumors, women who received taxane/platinum chemotherapy had survival comparable to those who received other regimens: 5-year rates for disease-free survival, 69.0% versus 70.1%, P = 0.98; and cause-specific survival, 80.0% versus 81.0%, P = 0.93. Similarly, in non-squamous tumors, disease-free survival (5-year rates: 60.4% versus 59.0%, P = 0.86) and cause-specific survival (74.7% versus 76.3%, P = 0.70) were similar. In conclusion, use of taxane/platinum regimens for NACT significantly increased during the study period. Irrespective of histology type, in women with clinical stage IB2-IIB cervical cancer who underwent NACT prior to radical hysterectomy, taxane/platinum regimens had a similar effect on survival compared to non-taxane/platinum regimens.

【 授权许可】

Unknown