Construction of an Immunogenomic Risk Score for Prognostication in Colon Cancer

Frontiers in Genetics

Han Zhang¹  Li Zhang¹  Chuan Qin²  Xiong Guo³  Hua Gan³ 

[1]Department of Digestive Oncology, Three Gorges Hospital, Chongqing University, Chongqing, China

[2]Department of Gastrointestinal Surgery, Three Gorges Hospital, Chongqing University, Chongqing, China

[3]First Clinical Medical College, Chongqing Medical University, Chongqing, China

关键词: immune-related genes;    immune system;    colon cancer;    prognostication;    biomarkers;   

DOI  :  10.3389/fgene.2020.00499

来源: DOAJ

【 摘 要 】

Immune-related genes (IRGs) play regulatory roles in the immune system and are involved in the initiation and progression of colon cancer. This study aimed to develop an immunogenomic risk score for predicting survival outcomes among colon cancer patients. We analyzed the expressions of IRGs in colon specimens and discovered 484 differentially expressed IRGs when we compared specimens from colon cancer and adjacent normal tissue. Univariate Cox regression analyses were performed to identify 26 IRGs that were associated with survival. A Cox proportional hazards model with a lasso penalty identified five optimal IRGs for constructing the immunogenomic risk score (CD1B, XCL1, PLCG2, NGF, and OXTR). The risk score had good performance in predicting overall survival among patients with colon cancer and was correlated with the amount of tumor-infiltrating immune cells. Our findings suggest that the immunogenomic risk score may be useful for prognostication in colon cancer cases. Furthermore, the five IRGs included in the risk score might be useful targets for investigating the initiation of colon cancer and designing personalized treatments.

【 授权许可】

Unknown